An anemic patient with phenotypical ?-thalassemic trait has elevated level of structurally normal ?-globin mRNA in reticulocytes
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منابع مشابه
Evaluation of salivary immunoglobulin A level in thalassemic patients with periodontitis in comparison with thalassemic patients with healthy periodontium
BACKGROUND AND AIM: This study was conducted to evaluate salivary immunoglobulin A (IgA) level in thalassemic patients with periodontitis in comparison to thalassemic patients with healthy periodontium.METHODS: Seventy-five patients were included in this study and were divided into three groups, group A: 25 major thalassemic patients with mild to moderate periodontitis, group B: 25 thalassemic ...
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In one form of beta-thalassemia, a genetic blood disorder, a mutation in intron 2 of the beta-globin gene (IVS2-654) causes aberrant splicing of beta-globin pre-mRNA and, consequently, beta-globin deficiency. Treatment of mammalian cells stably expressing the IVS2-654 human beta-globin gene with antisense oligonucleotides targeted at the aberrant splice sites restored correct splicing in a dose...
متن کاملRapid procedure for globin chain analysis in blood samples of normal and beta-thalassemic fetuses.
Reversed-phase high pressure liquid chromatography (HPLC) was used for the separation of the alpha, beta, (A)gamma and (G)gamma chains from human blood samples. The alpha and beta chains were normally eluted close together, but their separation was improved by coupling 2 or 3 columns in series, or by increasing the temperature of the columns. This method has been applied for the determination o...
متن کاملHemoglobin messenger RNA from human bone marrow. Isolation and translation in homozygous and heterozygous beta-thalassemia.
A method for isolating human hemoglobin messenger RNA (mRNA) from bone marrow cells was developed to investigate the molecular basis for the defect in globin synthesis in beta thalassemia. Active mRNA was isolated from the bone marrow cells and peripheral reticulocytes of patients with homozygous beta thalassemia, heterozygous beta thalassemia, sickle cell trait, double heterozygosity for beta ...
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ژورنال
عنوان ژورنال: American Journal of Hematology
سال: 2000
ISSN: 0361-8609,1096-8652
DOI: 10.1002/1096-8652(200011)65:3<243::aid-ajh12>3.0.co;2-6